| University Of Waterloo CA-E-V518-4SQP | Registered charity | Former | WATERLOO | $1.0B |
| IT/NET-Ottawa Inc. CA-E-XMGQ-8GDZ | Federal corporation | Active | Waterloo | $789.4M |
| Open Text Corporation CA-E-4G9R-H9RQ | Federal corporation | Active | Waterloo | $285.5M |
| Open Text Canada Ltd. CA-E-E0XY-8WKD | Federal corporation | Inactive | Waterloo | $94.0M |
| Crawford & Company (canada) INC. CA-E-VSJP-CKFY | Federal corporation | Active | Waterloo | $41.5M |
| Tamarack Institute For Community Engagement CA-E-ZCC0-TB2C | Registered charity | Former | WATERLOO | $37.8M |
| Wilfrid Laurier University CA-E-JFHZ-Z172 | Registered charity | Current | WATERLOO | $36.9M |
| Quantum Valley Ideas Laboratories CA-E-TEZE-WZ1P | Registered charity | Active | Waterloo | $26.1M |
| Arctic Research Foundation CA-E-N7ST-1FGQ | Registered charity | Active | Waterloo | $20.0M |
| English at First CA-E-PCQA-6Z98 | Registered charity | Active | WATERLOO | $18.9M |
| Mennonite Economic Development Associates of Canada CA-E-GMXD-Q634 | Registered charity | Active | WATERLOO | $18.6M |
| Perimeter Institute CA-E-YFF1-5P18 | Registered charity | Active | WATERLOO | $3.8M |
| Canadian Mennonite Publishing Service CA-E-ZE0B-PJRM | Registered charity | Active | WATERLOO | $2.4M |
| SB Centre for Security Governance CA-E-HM0D-JJ4K | Registered charity | Active | Waterloo | $1.2M |
| Verity Community Church CA-E-CR0C-SGN6 | Registered charity | Active | Waterloo | $943K |
| Canadian Clay And Glass Gallery CA-E-D7E9-4D6P | Registered charity | Active | Waterloo | $296K |
| Habitat For Humanity Waterloo Region INC CA-E-0N9A-PKD0 | Registered charity | Current | WATERLOO | $293K |
| Adventure4Change CA-E-93MT-4JPX | Registered charity | Active | Waterloo | $228K |
| Seeds of Diversity Canada CA-E-373Y-R1C8 | Registered charity | Active | WATERLOO | $224K |
| Karis Disability Services Foundation CA-E-Q196-VTN2 | Registered charity | Inactive | Waterloo | $149K |
| Creekside Church CA-E-MGS2-KCGZ | Registered charity | Active | WATERLOO | $81K |
| Chabad Lubavitch of the Waterloo Region CA-E-NFXP-RY91 | Registered charity | Active | WATERLOO | $80K |
| New Apostolic Church Canada CA-E-9GYH-0HS2 | Registered charity | Active | WATERLOO | $55K |
| Balsillie School of International Affairs CA-E-JMK5-ERZ6 | Registered charity | Active | Waterloo | $50K |
| Lincoln Road Chapel CA-E-T374-1ZBR | Registered charity | Active | WATERLOO | $37K |
| The Ripple Effect Education CA-E-48YH-96FW | Registered charity | Active | Waterloo | $23K |
| Waterloo Pentecostal Assembly CA-E-8S07-60FE | Registered charity | Active | WATERLOO | $21K |
| Huntington Society Of Canada CA-E-6XVK-CX0F | Registered charity | Active | Waterloo | $12K |
| Leilani's Hope CA-E-GD3B-79KC | Registered charity | Active | Waterloo | $9K |
| Bolivian Children Foundation CA-E-EXA8-YMBT | Registered charity | Active | Waterloo | $6K |